Author： Han Sehwan
Publisher： Springer Publishing Company
ISSN： 0167-6806
Source： Breast Cancer Research and Treatment, Vol.82, Iss.1, 2003-01, pp. : 11-16
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Abstract
The expressions of E2F1 and retinoblastoma protein (pRB) were analyzed in 165 lymph node-positive breast cancers. All patients underwent adjuvant chemotherapy with fluorouracil, doxorubicin and cyclophosphamide (FAC). E2F1 was expressed in 43.6% and pRB was expressed in 46.1%. E2F1 expression was significantly increased in pRB-expressing tumors and was associated with an S-phase fraction. By univariate survival analyses, E2F1 expression and ER were identified as significant prognostic factors</i> for disease recurrence and patient survival. E2F1 was the only significant prognostic factor</i> of patient outcome after FAC chemotherapy by multivariate analysis.
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