Author: Huh Jung
Publisher: Springer Publishing Company
ISSN: 1068-9265
Source: Annals of Surgical Oncology, Vol.17, Iss.10, 2010-10, pp. : 2640-2646
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Abstract
This study was designed to assess the prognostic value of the ratio of metastatic to resected lymph nodes (lymph node ratio [LNR]) in patients with node-positive colorectal cancer (CRC). From May 1998 to December 2007, data from a total of 514 patients who underwent curative surgery for CRC with proven lymph node metastases were analyzed. Patients were categorized into four groups on the basis of quartiles: LNR1 (<0.09), lnr2="" (between="" 0.09="" and="" 0.18),="" lnr3="" (="">0.18 and <0.34), and="" lnr4=""></0.34),> The median numbers of resected and metastatic nodes were 14 (range, 2–67) and 2 (range, 1–31), respectively. With a median follow-up period of 48.5 months, the 5-year overall survival rates of patients with LNR1, LNR2, LNR3, and LNR4 were 79, 72, 62, and 55%, respectively (P</i> < 0.001); the="" 5-year="" disease-free="" survival="" rates="" of="" patients="" with="" lnr1,="" lnr2,="" lnr3,="" and="" lnr4="" were="" 73,="" 67,="" 54,="" and="" 42%,="" respectively=""></ 0.001);>P</i> < 0.001). in="" the="" multivariate="" analysis,="" the="" lnr="" was="" an="" independent="" prognostic="" factor="" for="" both="" overall=""></ 0.001).>P</i> = 0.012) and disease-free survival (P</i> = 0.009), as were pT and pN category. LNR remained statistically significant both in patients with <12 and="" with="">12 nodes retrieved. In addition to the conventional pT and pN categories, the LNR was a predictor of both the overall and disease-free survival in patients with node-positive CRC. It may compensate for an inadequate lymph node dissection in surgery for CRC. </12></0.09),>