Acute Interactive Effects of Lindane and Dimethoate on Cerebral and Peripheral Tissues in Rats

Author： Chandra R. Prasad S. Srivastava S. Siddiqui M.K.J.

ISSN： 0277-2248

Source： Toxicological and Environmental Chemistry, Vol.82, Iss.1, 2002-01, pp. : 23-31

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Abstract

A number of studies have shown that interaction of certain combinations of pesticides can lead to enhancement of toxicity. In view of this, acute interactive effects of lindane and dimethoate were studied in rats randomized into four groups of six each. The first group was treated with lindane p.o. 10 mg/kg, the second group was treated with dimethoate p.o. 20 mg/kg, the third group was given dimethoate p.o. 20 mg/kg to rats pretreated (one hour before) with lindane p.o. 10 mg/kg and the fourth group serving as control was given oil only. The animals were sacrificed one hour after the exposure to determine the brain cortex and corpus striatum acetylcholinesterase (AChE) activity, blood glucose level, glycogen content in cerebral and peripheral tissues and free ammonia level in the brain. There was a si gnificantly greater inhibition of brain cortex and corpus striatum AChE activity (p<0.001) and="" enhancement="" of="" effect="" on="" free="" ammonia="" level="" in="" the="" brain="" of="" rats="">p<0.05) dosed="" with="" lindane="" +="" dimethoate="" than="" in="" rats="" treated="" either="" with="" lindane="" or="" dimethoate.="" the="" hyperglycemic="" action="" of="" both="" lindane="" and="" dimethoate="" when="" given="" alone="" was="" off-set="" in="" the="" group="" treated="" with="" both="" lindane="" and="" dimethoate="">p<0.05 and="" 0.001="" respectively).="" further,="" treatments="" with="" dimethoate="" of="" rats="" pretreated="" with="" lindane="" antagonised="" the="" effect="" of="" lindane="" on="" glycogen="" content="" in="" liver,="" brain="" and="" triceps="">p<0.05) but="" not="" in="" the="" diaphragm.="" the="" study="" signifies="" the="" importance="" of="" co-exposure="" in="" the="" risk="" assessment="" of="" chemicals="" in="" the="" environment="" laden="" with="" xenobiotics.="">