Author： Kruk Irena
Publisher： Taylor & Francis Ltd
ISSN： 0277-2248
Source： Toxicological and Environmental Chemistry, Vol.82, Iss.3-4, 2002-01, pp. : 113-128
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Despite beneficial effect of isoproterenol and doputamine, synthetic catecholamines rutinely used in intensive care patients, their high doses may contribute to cardiotoxicity. This study was conducted to examine whether these drugs can influence on Co, Cu - catalyzed generation deleterious reactive oxygen species (ROS) from H2O2 using chemiluminescent, spectrophotometric and ESR spin trapping techniques. The enhanced production of ROS from the Co(II)+H2O2 and Cu(II)+H2O2 systems in the presence of isoproterenol and dobutamine was observed. The ROS generation was inhibited by scavengers of superoxide anion radical $ {\rm (O}_{\rm 2}^{{ \bar\bullet }} {\rm )} $, hydroxyl radical $ ({\rm HO}^ \bullet ) $ scavengers and singlet oxygen (1O2) quenchers.
Related content
Access to resources
Recommend
Antioxidant and prooxidant action of eugenol-related compounds and their cytotoxicity
By Fujisawa S. Atsumi T. Kadoma Y. Sakagami H.
Toxicology, Vol. 177, Iss. 1, 2002-08 ,pp. :
The Bulletin of the Ecological Society of America, Vol. 92, Iss. 1, 2011-01 ,pp. :
The Bulletin of the Ecological Society of America, Vol. 96, Iss. 2, 2015-04 ,pp. :
Validation of MRI Measurement of Cardiac Output in the Dog: The Effects of Dobutamine and Minoxidil
By Hockings Paul D. Busza Albert L. Byrne Joanne Patel Bela Smart Sean C. Reid David G. Lloyd Heather L. White Alan Pointing Karen Farnfield Belinda A. Criado-Gonzalez Ana Whelan Greg A. Taylor Gemma L. Birmingham Jeffrey M. Slaughter Mark R. Osborne Janette A. Krebs-Brown Axel Templeton David
Toxicology Mechanisms and Methods, Vol. 13, Iss. 1, 2003-01 ,pp. :