Accelerating effect of sodium chloride on mexiletine adsorption onto activated charcoal

Author： Nakamura T. Oida Y. Kawasaki N. Tanada S. Tamura T.

ISSN： 0277-2248

Source： Toxicological and Environmental Chemistry, Vol.86, Iss.4, 2004-09, pp. : 207-211

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Abstract

The effective use of activated charcoal as an oral adsorbent for primary treatment of acute poisoning was investigated in vitro by evaluating the characteristics of mexiletine, an anti-arrhythmic drug, adsorbed onto activated charcoal in the presence of sodium chloride solutions at various concentrations. The equilibrium amount of mexiletine adsorbed onto activated charcoal was increased by the addition of sodium chloride. In particular, there was a marked increase in the amount adsorbed from a solution of lower mexiletine concentration. The removal rate is another important factor in the evaluation of activated charcoal, and a rapid decrease of mexiletine concentration by the addition of sodium chloride was recognized. The acceleration of mexiletine adsorption onto activated charcoal by the addition of sodium chloride was due to the occurrence of salting-out. It could be concluded that the administration of activated charcoal suspended in saline solution was more effective in the primary treatment of acute poisoning by mexiletine overdose.