Highly efficient synthesis and antitumor activity of monosaccharide saponins mimicking components of Chinese folk medicine Cordyceps sinensis

Author： Zhu Zhen-Yuan  

Publisher： Taylor & Francis Ltd

ISSN： 1028-6020

Source： Journal of Asian Natural Products Research, Vol.14, Iss.5, 2012-05, pp. : 429-435

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Abstract

Ergosterol 3-O-β-d-glucopyranoside (1a) and ergosterol 3-O-β-d-galactopyranoside (1b) were highly efficiently synthesized and evaluated for their inhibitory activities against two tumor cell lines. The structures of these compounds were extensively confirmed by 1H, 13C NMR, IR, and HRMS. Compounds 1a and 1b exhibited interesting cytotoxic profiles. The antitumor activity of compound 1a was higher than that of 1b.

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