EVALUATION OF URINARY D-GLUCARIC ACID EXCRETION IN WORKERS EXPOSED TO BUTYL GLYCOL

Author： Collinot J. P. Collinot J. C. Deschamps F. Decolin D. Siest G. Galteau M. M.

ISSN： 1087-2620

Source： Journal of Toxicology and Environmental Health, Vol.48, Iss.4, 1996-07, pp. : 349-358

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Abstract

The biological follow-up of subjects exposed to butyl glycol (BG) is generally accomplished using a standard blood count that is not sensitive enough to reveal early intoxication by this molecule. For this reason we have used an indirect test for evaluating the induction of hepatic enzymes, the measurement in urine of D-glucaric acid (DGA), which reflects the activity of the glucuronic acid enzyme pathway. This study was performed on 17 foundry workers exposed to BG emissions coming from paints used in cataphoresis. The airborne concentration of BG was less than 0.3 times the average limit exposure value. This study shows that BG emissions at low concentrations are able to increase the activity of the enzymes of the glucuronic acid pathway. DGA urinary excretion increased by 165% in winter (p<.01) and="" by="" 85%=""><.05) in="" summer="" when="" the="" doors="" are="" open="" and="" the="" bg="" concentration="" lower.="" dga="" urinary="" excretion="" is="" significantly="" higher="" in="" smoking="" than="" in="" nonsmoking="" exposed="" workers.="" none="" of="" these="" workers="" had="" a="" perturbed="" blood="" count.="" this="" study="" shows="" that="" the="" urinary="" level="" of="" dga="" provides="" a="" good="" test="" for="" the="" followup="" of="" exposure="" to="" bg="" in="" the="" electrophoresis="" painting="" plant,="" and="" that="" the="" exposed="" smoking="" workers="" seem="" to="" be="" more="" sensitive="" to="" bg="" exposure="" than="" do="" the="" nonsmokers.="" in="" conclusion,="" the="" measurement="" of="" urinary="" dga="" might="" be="" considered="" as="" a="" useful="" test="" for="" the="" surveillance="" of="" subjects="" exposed="" to="" vapors="" containing="" bg.="">