Author: Dijkstra K.
Publisher: Taylor & Francis Ltd
ISSN: 1473-0774
Source: Prenatal and Neonatal Medicine, Vol.6, Iss.2, 2001-04, pp. : 122-128
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Objective: We sought to determine whether cervicovaginal fluid matrix metalloproteinase-1 and -9 (MMP-1 and MMP-9) levels differed during pregnancy compared with those at term or in preterm labor. Study design: We used sensitive immunoassays to measure MMP-1 and MMP-9 levels in cervicovaginal secretions. Cases (n = 32) included women who delivered preterm, and were sampled more than 3 weeks prior to delivery (n = 19), within 1 week of delivery (n = 7), and during spontaneous labor (n = 6). Controls consisted of 80 women matched for race, age and gestational age, delivering at term and who were sampled at 20-32 weeks (n = 47), within 1 week of delivery (n = 14) and during term labor (n = 19). Results: Among cases and controls, cervicovaginal MMP-1 levels were low and unaffected by labor. Among non-laboring control patients, the median and range of MMP-9 concentrations were also low (0; 0-0.04 ng/ml), and these remained unchanged with advancing gestational age. However, MMP-9 levels increased significantly within 1 week of term labor (0.8; 0-22.8 ng/ml; p = 0.001) and during term labor (6.6; 0-30.6 ng/ml; p = 0.04), with the highest values observed among laboring patients with ruptured membranes (24.8; 19.2-30.6 ng/ml; p = 0.002). Among cases, MMP-9 concentrations were unaltered prior to preterm labor, but increased among patients in preterm labor (0.3; 0-30 ng/ml; p = 0.02). Conclusion: Cervicovaginal MMP-1 levels were low and unchanged during either preterm or term labor. In contrast, MMP-9 levels increased during term and preterm labor but did not predict preterm delivery in asymptomatic patients.
Related content
By Makrakis E. Grigoriou O. Kouskouni E. Vitoratos N. Salamalekis E. Chatzoudi E. Creatsas G.
Journal of Maternal-Fetal and Neonatal Medicine, Vol. 14, Iss. 3, 2003-09 ,pp. :
By Cheong Y.C. Shelton J.B. Laird S.M. Li T.-C. Ledger W.L. Cooke I.D.
Fertility and Sterility, Vol. 79, Iss. 5, 2003-05 ,pp. :
By Imai M. Tani A. Saito M. Saito K. Amano K. Nisijima M.
European Journal of Obstetrics and Gynecology and Reproductive Biology, Vol. 97, Iss. 1, 2001-07 ,pp. :
By Draper D. L. Kush M. J. Donohoe W. Janosky J. Latimer J. J. Heine R. P.
Prenatal and Neonatal Medicine, Vol. 6, Iss. 4, 2001-08 ,pp. :
By Edwin S. S. Romero R. Rathnasabapathy C. M. Athayde N. Armant D. R. Subramanian M. G.
Journal of Maternal-Fetal and Neonatal Medicine, Vol. 12, Iss. 4, 2002-10 ,pp. :