Author： Asai Yasuyuki
Publisher： VSP
ISSN： 1568-5527
Source： Advanced Powder Technology, Vol.16, Iss.4, 2005-08, pp. : 413-418
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Abstract
To obtain information on the effects of a divalent cation (Ca2+) on the membrane properties of the lipid A analog, E5531, the particle size, potential, membrane fluidity and pharmacokinetices was investigated in rats after the addition of calcium ion. Within a molar ratio for [Ca2+]/[E5531] 3, the presence of Ca2+ increased the potentials of the E5531 membrane, but had no effect on particle size. Ca2+ decreased membrane fluidity and the pharmacokinetics in rats. These effects of Ca2+ on the membrane properties of E5531 particles could be eliminated by the addition of EDTA.
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