Cicatrizing and antimicrobial properties of an ozonised oil from sunflower seeds

Publisher： VSP

ISSN： 1568-5608

Source： Inflammopharmacology, Vol.12, Iss.3, 2004-01, pp. : 261-270

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

The ozonised sunflower oil, Bioperoxoil^®, was tested for its antimicrobial activity against some pathological strains in vitro together with its healing potential against Staphylococcus aureus in vivo. Bioperoxoil^® was tested against S. aureus, Pseudomonas aeroginosa, Candida albicans, S. typhimurium and Escherichia coli suspensions using the agar diffusion method. Healing experiments were carried out with Wistar rats through topical application of 3.5 mg/ml of the ozonised oil up to the 7th day after inoculation with S. aureus. Bioperoxoil^® showed anti-inflammatory effects against all strains tested, with MIC values ranging from 2.0 to 3.5 mg/ml. Bioperoxoil^® also demonstrated protective effects on skin connective tissue and to enhance wound healing during the treatment, as compared to a neomycin–clostebol association used as a positive control. The overall results indicated a significant antimicrobial activity, anti-inflammatory and wound-healing properties for Bioperoxoil^®, as compared to other antimicrobial agents commercially available.