Is There Evidence for Convergent Evolution around Human Microsatellites?

Author: Webster Matthew T.   Hagberg Jonas  

Publisher: Oxford University Press

ISSN: 0737-4038

Source: Molecular Biology and Evolution, Vol.24, Iss.5, 2007-05, pp. : 1097-1100

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Abstract

A study by Vowles and Amos (2004) identified atypical patterns of base composition around human microsatellites and argued that microsatellites generate mutational biases in their flanking regions. Here, we perform simulations of molecular evolution using a simple model that suggest similar patterns can be produced without any such biases in genome evolution.

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