Author： Choo Yeun Su Vogler Georg Wang Danling Kalvakuri Sreehari Iliuk Anton Tao W. Andy Bodmer Rolf Zhang Zhuohua
Publisher： Oxford University Press
ISSN： 1460-2083
Source： Human Molecular Genetics, Vol.21, Iss.11, 2012-06, pp. : 2514-2523
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Abstract
Neddylation is a posttranslational modification that plays important roles in regulating protein structure and function by covalently conjugating NEDD8, an ubiquitin-like small molecule, to the substrate. Here, we report that Parkinson's disease (PD)-related parkin and PINK1 are NEDD8 conjugated. Neddylation of parkin and PINK1 results in increased E3 ligase activity of parkin and selective stabilization of the 55 kDa PINK1 fragment. Expression of
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