Ontogeny of gonadotrophin and inhibin secretion in normal girls through puberty based on overnight serial sampling and a comparison with normal boys.

Author： Manasco P K Umbach D M Muly S M Godwin D C Negro-Vilar A Culler M D Underwood L E

Publisher： Oxford University Press

ISSN： 1460-2350

Source： Human Reproduction, Vol.12, Iss.10, 1997-10, pp. : 2108-2114

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Abstract

We measured luteinizing hormone (LH) and follicle stimulating hormone (FSH) by immunofluorometric assays and alpha-inhibin by radioimmunoassay in serum sampled every 10 min throughout the night (2100-0500 h) from 44 normal girls. Mean overnight LH values rose log-linearly from a mean of 0.2 IU/l in prepubertal girls to 3.0 IU/l in late pubertal girls. Log2 mean overnight FSH rose rapidly through early puberty and then remained constant; mean FSH rose from 1.0 IU/l in prepubertal girls to approximately 2.8 IU/l in Tanner III-V girls. Mean overnight inhibin increased through puberty, rising from 151 ng/l in prepubertal girls to 432 ng/l in fully pubescent girls. Within each of the first three Tanner stages, LH differed approximately 100-fold between the smallest and largest mean concentrations but differed <10-fold within="" stages="" iv="" or="" v.="" such="" within-pubertal="" stage="" variability="" was="" less="" pronounced="" for="" fsh,="" which="" differed="" approximately="" 16-fold="" among="" tanner="" i="" subjects="" and="" 4-10-fold="" at="" later="" stages,="" and="" for="" inhibin,="" which="" varied="" approximately="" 4-fold="" within="" each="" tanner="" stage.="" the="" frequency="" of="" lh="" pulses="" during="" overnight="" sampling="" increased="" significantly="" during="" puberty,="" but="" the="" frequency="" of="" fsh="" and="" inhibin="" pulses="" remained="" constant.="" we="" compared="" the="" results="" from="" girls="" to="" those="" from="" 50="" normal="" boys="" [manasco="" et="" al.="" (1995)="" j.="" clin.="" endocrinol.="" metab.,="" 80,="" 20462052].="" at="" each="" pubertal="" stage,="" girls="" had="" approximately="" the="" same="" mean="" overnight="" lh="" values="" as="" boys;="" girls="" had="" higher="" mean="" overnight="" fsh,="" particularly="" during="" tanner="" stages="" ii-iv;="" and="" boys="" had="" mean="" overnight="" alpha-inhibin="" immunoreactivity="" approximately="" 1.5="" times="" that="" of="" girls="" at="" each="" pubertal="" stage.="" still,="" hormone="" concentrations="" for="" individuals="" of="" both="" sexes="" intergraded="" at="" each="" pubertal="" stage.="">