A prospective, randomized, cross-over comparison of two methods of artificial insemination by donor on the incidence of conception: intracervical insemination by straw versus cervical cap.

Author： Flierman P A Hogerzeil H V Hemrika D J

Publisher： Oxford University Press

ISSN： 1460-2350

Source： Human Reproduction, Vol.12, Iss.9, 1997-09, pp. : 1945-1948

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Abstract

In a prospective, randomized study of insemination with donor semen, intracervical insemination by straw was compared with insemination using a cervical cap with an intracervical reservoir. A total of 91 patients completed 486 treatment cycles. There were no significant differences in age, parity, indication for insemination by donor, or method of cycle monitoring between women who became pregnant and those who did not conceive with either insemination method. In 236 standard intracervical insemination cycles, 14 patients became pregnant (5.9% per cycle), whereas 38 patients conceived in 250 cervical cap cycles (15.2% per cycle). Both the crude pregnancy rates and the cumulative pregnancy rates calculated by the Kaplan-Meier life-table method were significantly different (chi(2)-test, P < 0.001,="" and="" log-rank="" test,="" p="">< 0.005="" respectively).="" pregnancy="" rates="" in="" artificial="" insemination="" with="" cryopreserved="" donor="" semen="" may="" be="" improved="" by="" the="" use="" of="" a="" cervical="" cap="" when="" compared="" to="" cervical="" insemination="" by="" straw.="" the="" use="" of="" the="" cervical="" cap="" may="" prolong="" the="" exposure="" of="" the="" spermatozoa="" to="" the="" cervical="" mucus="" and="" prevent="" the="" backflow="" of="" semen="" into="" the="" vagina.="">