Comparison of pregnancy outcome after intracytoplasmic sperm injection and in-vitro fertilization

Author： Govaerts I Devreker F Koenig I Place I Van den Bergh M Englert Y

ISSN： 1460-2350

Source： Human Reproduction, Vol.13, Iss.6, 1998-06, pp. : 1514-1518

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Abstract

The aim of this study was to compare pregnancy characteristics and perinatal outcome of intracytoplasmic sperm injection (ICSI) pregnancies with pregnancies obtained after in-vitro fertilization (IVF). Retrospectively, 145 ICSI pregnancies were matched with 145 IVF pregnancies using the last menstruation data. The main outcome measures were preclinical and clinical abortions, ectopic pregnancies, multiple gestations, prenatal morbidity, prematurity, Caesarean section, birthweight, perinatal mortality and malformations for singletons, twins and triplets. Although patients were significantly younger (P < 0.001)="" in="" icsi="" (31="" years)="" than="" in="" ivf="" (33="" years),="" their="" infertility="" duration="" (5="" years)="" was="" similar.="" the="" mean="" number="" of="" transferred="" embryos="" (2.7="" embryos="" per="" transfer)="" was="" similar="" in="" ivf="" and="" icsi.="" the="" rates="" of="" preclinical="" (15%)="" and="" clinical="" abortions="" (11%="" in="" icsi="" versus="" 15%="" in="" ivf)="" were="" not="" different.="" four="" ectopic="" pregnancies="" were="" observed="" in="" the="" ivf="" group="" and="" none="" in="" the="" icsi="" group.="" in="" icsi,="" two="" minor="" malformations="" were="" detected="" and="" two="" therapeutic="" abortions="" were="" performed="" respectively="" for="" polymalformations="" and="" suspicion="" of="" cystic="" fibrosis.="" the="" rate="" of="" congenital="" malformation="" was="" 2.8%="" in="" icsi="" and="" 2.2%="" in="" ivf.="" in="" this="" last="" group,="" one="" therapeutic="" abortion="" for="" malformation="" of="" neural="" tube="" was="" performed="" and="" two="" minor="" malformations="" were="" detected.="" the="" rate="" of="" aborted="" embryonic="" sacs="" before="" 16="" weeks="" of="" gestation="" was="" not="" significantly="" lower="" in="" icsi="" compared="" with="" ivf="" (13.7%="" versus="" 20%).="" the="" rate="" of="" multiple="" gestations="" was="" similar="" in="" both="" groups="" (31%="" in="" ivf="" and="" 35%="" in="" icsi).="" the="" number="" of="" caesarean="" sections="" was="" similar="" in="" ivf="" and="" icsi="" and="" was="" twice="" as="" frequent="" for="" twins="" versus="" singletons.="" the="" number="" of="" singletons="" born="" by="" caesarean="" section="" was="" 21%="" after="" icsi="" and="" 17&="" after="" ivf.="" mean="" birthweights="" and="" gestational="" ages="" at="" birth="" for="" twins="" were="" significantly="" higher="">P < 0.05)="" in="" icsi="" than="" in="" ivf="" (2488="" versus="" 2281="" g="" and="" 36.5="" versus="" 35.5="" weeks).="" this="" difference="" was="" not="" observed="" for="" singletons.="" in="" conclusion,="" pregnancy="" characteristics="" and="" perinatal="" outcome="" after="" icsi="" showed="" no="" increase="" in="" the="" number="" of="" pathologies="" in="" comparison="" with=""> Keywords:ICSI/IVF/perinatal outcome/pregnancy characteristics