Extremes of body mass do not adversely affect the outcome of superovulation and in-vitro fertilization

ISSN： 1460-2350

Source： Human Reproduction, Vol.14, Iss.3, 1999-03, pp. : 712-715

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Abstract

The effect of extremes of body mass on ovulation is well recognized by clinicians. However, the effect of obesity and extreme underweight on the outcome of in-vitro fertilization (IVF) cycles has received relatively little attention. In a retrospective nested case-control study we examined the effect of the extremes of body mass index (BMI) on IVF-embryo transfer outcome at a university-based IVF unit. A total of 333 patients were included in the study; 76 obese patients (BMI > 27.9) with 152 controls, and 35 underweight patients (BMI < 19)="" with="" 70="" controls.="" the="" patients="" were="" matched="" with="" their="" controls="" in="" age="" ±="" 1="" year,="" day="" 3="" follicle="" stimulating="" hormone="" (fsh)="" concentration,="" daily="" dose="" of="" gonadotrophin="" (±="" 37.25="" iu),="" gonadotrophin="" preparation="" and="" the="" year="" of="" treatment.="" the="" following="" parameters="" were="" compared="" between="" the="" study="" and="" control="" groups:="" duration="" of="" administration="" and="" dose="" of="" gonadotrophin,="" number="" of="" follicles="" aspirated,="" number="" of="" eggs,="" fertilization="" rate,="" number="" of="" embryos,="" serum="" oestradiol="" concentration="" on="" human="" chorionic="" gonadotrophin="" (hcg)="" day="" (peak="" oestradiol),="" clinical="" pregnancy="" rate,="" implantation="" rate,="" miscarriage="" rate,="" and="" incidence="" of="" ovarian="" hyperstimulation="" syndrome.="" apart="" from="" a="" significantly="" lower="" peak="" oestradiol="" concentration="">P = 0.009) in the obese patients, they and the underweight patients were not significantly different from their normal controls. The extremes of body mass index do not adversely affect the outcome of IVF-embryo transfer treatment. However, the obese patients had lower peak oestradiol concentrations than their normal controls despite receiving similar gonadotrophin doses. Keywords: body mass index/IVF-embryo transfer/obesity/underweight