Rescue ICSI of unfertilized oocytes after IVF

ISSN： 1460-2350

Source： Human Reproduction, Vol.17, Iss.9, 2002-09, pp. : 2423-2427

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Abstract

BACKGROUND: Failed fertilization after IVF occurs in 10–20% of cycles. Conflicting results of rescue fertilization by ICSI have been reported. We therefore compared the success rate in terms of fertilization and pregnancy of cycles in which rescue ICSI was performed with those from a matched control group of primarily ICSI cycles. METHODS: Unfertilized oocytes from IVF cycles with total fertilization failure where at least four metaphase II oocytes were available were treated by ICSI (group I; n = 120). A matched control group was established with patients undergoing ICSI during the same period (group II; n = 280). RESULTS: Both fertilization rate and the proportion of embryos with four blastomeres on day 2 after ICSI were significantly higher in the control group (P < 0.05).="" embryo="" quality,="" however,="" was="" comparable="" in="" both="" groups.="" the="" pregnancy="" rate="" in="" the="" control="" group="" was="" 25.3%="" whereas="" in="" group="" i="" with="" rescue="" icsi,="" no="" pregnancy="" was="" obtained.="" conclusions:="" although="" unfertilized="" oocytes="" after="" ivf="" can="" be="" fertilized="" by="" icsi,="" the="" developmental="" potential="" of="" the="" ensuing="" embryos="" is="" very="" poor.="" therefore,="" rescue="" icsi="" after="" total="" failure="" of="" fertilization="" is="" not="" recommended.="">