Author： Feng Lili
Publisher： Humana Press, Inc
ISSN： 0257-277X
Source： Immunologic Research, Vol.21, Iss.2-3, 2000-06, pp. : 203-210
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Chemokines are first noted for their ability to attract and activate leukocytes, as well as their potential role as mediators of inflammation. However, emerging data have shown that various chemokines may exert, other biologic effects both inside and outside the immune system. Inducible chemokines participate primarily in inflammatory responses and comprise the bulk of the chemokine family. Constitutive chemokines are expressed primarily in secondary lymphoid organs and some nonlymphoid organs, where they play amajor role in lymphocyte homing. Studies expanding to areas beyond inflammatory leukocyte recruitment, will likely give us a more complete picture of chemokine function, its regulation in lymphoid and nonlymphoid tissues and ways of utilizing endogenous chemokines to intervene with immune and inflammatory reactions.
Related content
Access to resources
Recommend
Chemokines in inflammation and immunity
Immunology Today, Vol. 21, Iss. 9, 2000-09 ,pp. :
The Role of Mast Cells and Basophils in Immunoregulation
By Nolte H.
Allergy and Asthma Proceedings, Vol. 17, Iss. 1, 1996-01 ,pp. :
By Penido Carmen Costa Maria F. S. Souza Mariana C. Costa Karina A. Canda Andre L. P. Benjamim Claudia F. Henriques Maria das Graas M. O.
International Immunology, Vol. 20, Iss. 1, 2008-01 ,pp. :
Role of Chemokines in Leishmania Infection
Current Molecular Medicine, Vol. 4, Iss. 6, 2004-09 ,pp. :