Immune response and immunotherapy to Cryptococcus infections

Author: Zhou Qing   Murphy William  

Publisher: Humana Press, Inc

ISSN: 0257-277X

Source: Immunologic Research, Vol.35, Iss.3, 2006-10, pp. : 191-207

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Abstract

Cryptococcus neoformans is a ubiquitous fungus that can cause lifethreatening infections during immunosuppressive states such as acquired immunodeficiency syndrome (AIDS) and after bone marrow transplantation (BMT). Infected individuals normally succumb to meningitis and meningoencephalitis caused by dissemination of C. neoformans to the brain. In this review, we analyze the current understanding of the interaction between host immune response and C. neoformans as well as the current state of immunotherapeutic strategies for treating cryptococcosis.

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