Author： Watanabe Masahiro Yamamoto Takenori Yamamoto Atsushi Obana Eriko Niiyama Kanami Hada Takuya Ooie Toshihiko Kataoka Masatoshi Hori Tomoshige Houchi Hitoshi Shinohara Yasuo
Publisher： Humana Press, Inc
ISSN： 0273-2289
Source： Applied Biochemistry and Biotechnology, Vol.165, Iss.2, 2011-09, pp. : 538-547
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Abstract
The thermogenic function of brown adipose tissue (BAT) is known to be markedly elevated when animals are exposed to the cold, and intensive studies have been carried out to understand the molecular basis enabling effective thermogenesis in cold-exposed animals. In this study, we used microarray analysis to examine the effects of cold exposure of animals on their gene expression profiles in white adipose tissue (WAT), which seems to function as a counterpart tissue of BAT. The results indicate that the effects of cold exposure on the gene expression profiles of WAT were much more moderate than the effects on those of BAT. Possible reasons for the different responses of BAT and WAT to cold exposure are discussed.
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