Author： Klivenyi Peter Gardian Gabrielle Calingasan Noel Yang Lichuan Beal M.
Publisher： Humana Press, Inc
ISSN： 0895-8696
Source： Journal of Molecular Neuroscience, Vol.21, Iss.3, 2003-10, pp. : 191-198
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Abstract
There is evidence that both inflammatory mechanisms and mitochondrial dysfunction contribute to Parkinson’s disease (PD) pathogenesis. We investigated whether the cyclooxygenase 2 (COX-2) inhibitor rofecoxib either alone or in combination with creatine could exert neuroprotective effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine model of PD in mice. Both rofecoxib and creatine administered alone protected against striatal dopamine depletions and loss of substantia nigra tyrosine hydroxylase immunoreactive neurons. Administration of rofecoxib with creatine produced significant additive neuroprotective effects against dopamine depletions. These results suggest that a combination of a COX-2 inhibitor with creatine might be a useful neuroprotective strategy for PD.
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