Author： Buchs Andreas Zehavi Sergei Sher Osnat Yeheskely Eyal Muggia-Sulam Michael Sherman Yoav Rapoport Micha
Publisher： Humana Press, Inc
ISSN： 0969-711X
Source： Endocrine Journal, Vol.22, Iss.2, 2003-11, pp. : 81-83
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Abstract
Objective: Heparanase, galectin-3, and tissue factor (TF) are overexpressed in solid malignant thyroid tumors. We studied their expression in multinodular goiters (MNGs).Design and Methods: Thyroid tissue specimens from 15 MNGs were obtained during surgery. mRNA expression for galectin-3, heparanase, and TF was assessed by RT-PCR.Results: Isolated expressions of heparanase and galectin-3 mRNA were expressed in 2 and 4 of the 15 MNGs, respectively; 8/15 MNGs were positive for both heparanase and galectin-3. TF mRNA was found in all MNG specimens.Conclusion: Galectin-3, heparanase, and TF RNA expression is prevalent in MNGs. Further studies will be needed to determine the prognostic significance of these findings.
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