Author： Erem Cihangir Hacihasanoglu Arif Cinel Akif Çobanoglu Ümit Ersöz Halil Ahmetoglu Ali Ukinç Kubilay Koçak Mustafa
Publisher： Humana Press, Inc
ISSN： 0969-711X
Source： Endocrine Journal, Vol.25, Iss.3, 2004-12, pp. : 253-257
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Abstract
We report a case of adrenal black adenoma associated with Cushing’s syndrome. A 41-yr-old man presented to our hospital with a 6-yr history of severe hypertension and general fatigue, and a 1-mo history of diabetes mellitus. Physical examination disclosed cushing-oid manifestations. His serum cortisol concentrations ranged from 14.0 to 15.4 µg/dL, with an ACTH level <5 pg/mL. Urinary free cortisol level was increased (125 µg/d). Cortisol was not suppressed on the overnight 1 mg oral dexamethasone suppression test (DST), 2-d low-dose DST, and 2-d high-dose DST. Abdominal computed tomography and magnetic resonance imaging studies revealed a solid round tumor approx 3 cm in diameter, located in the left adrenal gland. Left adrenalectomy was performed; the surgical specimen revealed a black adenoma consisting of compact cells within numerous pigments that seemed to be lipofuscin in nature.
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