

Author: Hagiwara Hanae Usui Takeshi Kimura Takashi Tagami Tetsuya Naruse Mitsuhide Minamiguchi Sachiko Kato Takuma Okuno Hiroshi Shimatsu Akira
Publisher: Humana Press, Inc
ISSN: 1046-3976
Source: Endocrine Pathology, Vol.19, Iss.2, 2008-06, pp. : 122-127
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Abstract
Myelolipomas of the adrenal gland are benign, nonfunctioning tumors. Patients with congenital adrenal hyperplasia sometimes develop large and bilateral myelolipomas. Although the precise pathogenesis of myelolipomas remains unclear, prolonged stimulation with high levels of adrenocorticotropic hormone (ACTH) or adrenal androgens are assumed to have a causative role. To clarify the role of ACTH and androgen in the pathogenesis of myelolipoma, we report a case of giant adrenal myelolipoma in a patient with poorly controlled congenital adrenal hyperplasia. A 43-year-old female was diagnosed with congenital adrenal hyperplasia at 6 years of age because of ambiguous genitalia. She had high plasma ACTH and 17-hydroxyprogesterone levels. Abdominal computed tomography showed a huge mass on the left adrenal gland, and an enlarged right adrenal mass. Genetic testing for
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