Author: Ryves W. Harwood Adrian
Publisher: Humana Press, Inc
ISSN: 1073-6085
Source: Molecular Biotechnology, Vol.33, Iss.2, 2006-06, pp. : 123-131
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Abstract
The plasma membrane is an effective barrier to most macromolecules and hydrophilic molecules. Remarkably, a class of positively charged cell-penetrating peptides (CPPs) has been discovered that can translocate themselves and associated cargoes into the cytoplasm. These have been used to carry oligopeptide- and oligonucleotide-based inhibitors into mammalian cells. A recent report indicates that the same CPPs are internalized by plant protoplasts, suggesting that this may be a universal phenomenon. We report here that the prototypical CPP, penetratin, enters cells of the free-living amoebae
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