Author： Liu Edwin Li Marcella Jasinski Jean Kobayashi Masakazu Gianani Roberto Nakayama Maki Eisenbarth George
Publisher： Humana Press, Inc
ISSN： 1085-9195
Source： Cell Biochemistry and Biophysics, Vol.48, Iss.2-3, 2007-07, pp. : 177-182
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Abstract
Even though there are numerous autoantigens for type 1 diabetes, current evidence suggests that a single autoantigen, namely insulin, is responsible for the key initiating event in autoimmunity. If a single autoantigen is necessary for triggering the autoimmune process, then antigen-specific therapy to block or delete the immune response against that autoantigen before epitope spreading occurs, may become a larger focus of future immunotherapeutic strategies. In this article, we review current literature regarding insulin as an autoantigen and potential approaches to deleting insulin-reactive T cells through the use of peptide vaccines and targeted T cell receptor immunizations.
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