Author： Monshausen Michaela Gehring Niels H. Kosik Kenneth S.
Publisher： Humana Press, Inc
ISSN： 1535-1084
Source： NeuroMolecular Medicine, Vol.6, Iss.2-3, 2004-10, pp. : 127-144
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Members of the Staufen family of RNA-binding proteins are highly conserved cytoplasmic RNA transporters associated with RNA granules. staufen2 is specifically expressed in neurons where the delivery of RNA to dendrites is thought to have a role in plasticity. We found that Staufen2 interacts with the nuclear pore protein p62, with the RNA export protein Tap and with the exon–exon junction complex (EJC) proteins Y14–Mago. The interaction of Staufen2 with the Y14-Mago heterodimer seems to represent a highly conserved complex as the same proteins are involved in the Staufen-mediated localization of oskar mRNA in Drosophila oocytes. A pool of Staufen2 is present in neuronal nuclei and colocalizes to a large degree with p62 and partly with Tap, Y14, and Mago. We suggest a model whereby a set of conserved genes in the oskar mRNA export pathway may be recruited to direct a dendritic destination for mRNAs originating as a Staufen2 nuclear complex.
Related content
By Anderson K.D. Merhege M.A. Morin M. Bolognani F. Perrone-Bizzozero N.I.
Experimental Neurology, Vol. 183, Iss. 1, 2003-09 ,pp. :
Access to resources
Recommend
