Author： Hon Yung-Son Hsieh Cheng-Han Chen Hsien-Fan
Publisher： Taylor & Francis Ltd
ISSN： 0039-7911
Source： Synthetic Communications, Vol.37, Iss.10, 2007-01, pp. : 1635-1651
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Abstract
A diastereoselective formal total synthesis of (±)-nephrosteranic acid (10) is described. The key step is to introduce the α-methylene group by the ozonolysis of monosubstituted alkenes followed by reaction with a preheated mixture of CH2Br2-Et2NH. The α-methyl group of compound 10 was formed from the reduction of the corresponding α-methylene precursor.
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