Author： Anasuyamma U. Haranath P. Kumar M. Anil Reddy C. Suresh Raju C. Naga
Publisher： Taylor & Francis Ltd
ISSN： 0039-7911
Source： Synthetic Communications, Vol.37, Iss.19, 2007-01, pp. : 3429-3437
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Abstract
1-[(Substituted carbamoyl)amino]-1H,3H-1λ5-[1,3,2]oxazaphospholo[3,4-a]benzimidazol-1-ones were synthesized by reacting benzimidazole 2-methanol (4) with different chlorides of carbamidophosphoric acids (3) in the presence of triethylamine at 40-45°C. Their 1H, 13C, and 31P NMR spectral data were discussed. The title compounds were tested for their activity against the fungi Aspergillus niger and Fusarium solani and bacteria Staphylococcus aureus and Escherichia coli. These compounds showed moderate antibacterial activity when compared with antifungal activity.
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