One-Pot Etherification of Ketones and Aldehydes with Organic Halides Using Sodium Hydride as a Reductant

Author: Meng Qingwei   Gong Bin   Hui Chuang   Gao Zhanxian  

Publisher: Taylor & Francis Ltd

ISSN: 0039-7911

Source: Synthetic Communications, Vol.39, Iss.10, 2009-01, pp. : 1708-1717

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Abstract

One-pot etherification reaction of aromatic and some aliphatic carbonyl compounds with organic halides in the presence of sodium hydride as a reducing reagent proceeded smoothly in dioxane, a polar solvent with higher boiling point, to provide desired ethers in moderate to high yields.