Efficient Synthesis of Olmesartan Medoxomil, an Antihypertensive Drug

Author: Babu Karrothu Srihari   Reddy Mallepalli Srinivasa   Tagore Amirisetty Ravindranath   Reddy Gade Srinivas   Sebastian Sony   Varma Mudunuru Satish   Venkateswarlu Gandu   Bhattacharya Apurba   Reddy Padi Pratap   Anand Ramasamy Vijaya  

Publisher: Taylor & Francis Ltd

ISSN: 0039-7911

Source: Synthetic Communications, Vol.39, Iss.2, 2009-01, pp. : 291-298

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Abstract

This document describes a simple and robust process for the synthesis of olmesartan medoxomil. This tailored process allows us to synthesize olmesartan medoxomil on a large scale with 50% overall yield. Also, our process has excellent control of the impurity profile in all the stages.

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