Author： Rao Somisetti Narender Sitaramaiah Devarasetty Srimannarayana Kema Rao Challa Nageswar Rao Peddi Srinivasa Babu K. Sudhakar
Publisher： Taylor & Francis Ltd
ISSN： 0039-7911
Source： Synthetic Communications, Vol.41, Iss.1, 2011-01, pp. : 85-93
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Abstract
Carvedilol (Coreg) is a nonselective β-adrenergic blocking agent with vasodilating activity. It is used for the treatment of congestive heart failure and hypertension. During the bulk synthesis of carvedilol, we have observed six impurities: Imp-I, Imp-II, Imp-III, Imp-IV, Imp-V, and Imp-VI. The present work describes the synthesis and characterization of these impurities.
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