Author： Jahr Norbert Hädrich Nicole Anwar Mamuna Csaki Andrea Stranik Ondra Fritzsche Wolfgang
Publisher： Taylor & Francis Ltd
ISSN： 0306-7319
Source： International Journal of Environmental and Analytical Chemistry, Vol.93, Iss.2, 2013-02, pp. : 140-151
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Abstract
A novel scheme for the optical detection of a few or even single gold nanoparticle labels is introduced. It utilizes sub-wavelength holes in a chromium layer on a glass substrate, where a bioaffinity reaction could take place and the outcome (regarding particle label binding) can be monitored using optical means. Experiments in combination with simulations demonstrate that the presence of particles in such a chromium hole can be simply detected by using the color information of images by a charge couple device (CCD) camera without the need for additional spectroscopy setups. The presence of gold nanoparticles leads to a detectable red-shift in the images of the respective nanohole, which is the sensing principle of the sensor.
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