Author： Khan Zarine Shervington Amal Munje Chinmay Shervington Leroy
Publisher： Informa Healthcare
ISSN： 0735-7907
Source： Cancer Investigation, Vol.31, Iss.6, 2013-07, pp. : 404-411
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The efficacy of glioma therapy can be considerably improved if it eliminates cancer stem cells (CSCs); however, to achieve this, CSCs markers are required. This study investigated the influence of micro-environmental changes on CSCs in hypoxic, serum deprived U87-MG and the corresponding control cells. Proteomic analysis produced a wide dataset, depicting the changes that occur at the proteomic level in the differentiated and undifferentiated U87-MG cell line. With the IPA analysis, HPRD and literature reviews, 11 proteins were proposed as potential differentiated biomarkers for CSCs namely Hsp90β1, vimentin, PGK1, GAPDH, EIF4e, TPI1, HspA8, HNRNPK, NAMPT, CCSNK2A1, and ANXA2.
Related content
Challenges and strategies for identifying biomarkers for colorectal cancer
Colorectal Cancer, Vol. 2, Iss. 6, 2013-12 ,pp. :
Access to resources
Recommend
