Deprivation Amblyopia and Congenital Hereditary Cataract

Author： Mansouri Behzad Stacy Rebecca C. Kruger Joshua Cestari Dean M.

ISSN： 0882-0538

Source： Seminars in Ophthalmology, Vol.28, Iss.5-6, 2013-09, pp. : 321-326

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Abstract

AbstractAmblyopia is a neurodevelopmental disorder of vision associated with decreased visual acuity, poor or absent stereopsis, and suppression of information from one eye.1^,2 Amblyopia may be caused by strabismus (strabismic amblyopia), refractive error (anisometropic amblyopia), or deprivation from obstructed vision (deprivation amblyopia).1 In the developed world, amblyopia is the most common cause of childhood visual impairment,3 which reduces quality of life4 and also almost doubles the lifetime risk of legal blindness.5^,6 Successful treatment of amblyopia greatly depends on early detection and treatment of predisposing disorders such as congenital cataract, which is the most common cause of deprivational amblyopia. Understanding the genetic causes of congenital cataract leads to more effective screening tests, early detection and treatment of infants and children who are at high risk for hereditary congenital cataract.