Determination of reference values for urinary neutrophil gelatinase-associated lipocalin in premature infants

Author： Elmas Ahmet Taner Tabel Yılmaz İpek Sevcan

ISSN： 1476-4954

Source： Journal of Maternal-Fetal and Neonatal Medicine, Vol.27, Iss.2, 2014-01, pp. : 187-191

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Abstract

AbstractBackground: The aim of this study is to determine the reference values of urinary neutrophil gelatinase-associated lipocalin (uNGAL) in healthy very preterm infants.Method: The study was performed on 30 preterm infants whose gestational ages (GA) were between 28 and 34 weeks. They were divided into three groups according to the GA as group 1: GA 28–29 weeks, group 2: 30–32 weeks and group 3: 33–34 weeks. Blood and urine samples were obtained on postnatal (PN) days 1 and 7. uNGAL was measured by ELISA.Results: There were 10 preterm infants for each group. The median values of uNGAL on PN Days 1 were 19.80 (8.6–25.7) ng/ml, 9.25 (1.42–30.3) ng/ml, and 7.95 (1.60-27.8) ng/ml in group 1, group 2 and group 3, respectively. Multivariate linear regression analysis showed that uNGAL values are not associated with GA, birth weight, and gender in preterm infants on PN Days 1 and 7.Conclusion: Our study indicated that normal values of uNGAL concentrations in healthy very preterm infants, and older children or adults are similar preterm infants.