Perinatal exposure to fluoxetine via placenta and lactation inhibits the testicular development in male rat offspring

Author： de Oliveira Waldo Monteiro   de Sá Iana Raphaela   de Torres Sandra Maria   de Morais Rosana Nogueira   Andrade Anderson Martino   Maia Frederico Celso Lyra   Tenorio Bruno Mendes   da Silva Junior Valdemiro Amaro  

Publisher： Informa Healthcare

ISSN： 1939-6368

Source： Systems Biology in Reproductive Medicine, Vol.59, Iss.5, 2013-10, pp. : 244-250

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Abstract

Due to the widespread use of fluoxetine to treat depression, including pregnant and nursing women, the present study aimed to investigate the effects of in utero and lactational exposure to fluoxetine in rat offspring at post natal day 22. Wistar rat dams were orally treated with fluoxetine (5, 10, and 20 mg/kg) from day 13 gestation to day 21 lactation. Exposure to 10 and 20 mg/kg fluoxetine reduced the body and testis weights. The volume of the seminiferous tubules and epithelium were also reduced following 20 mg/kg fluoxetine exposure. The length of the seminiferous tubules and the population of Sertoli cells changed in offspring exposed to fluoxetine. The amount of seminiferous tubules lacking tubular lumen was higher in rats exposed to 20 mg/kg fluoxetine. Plasma testosterone showed no significant change. In conclusion, fluoxetine exposure via the placenta and lactation may inhibit and delay testicular development, adversely affecting several testicular parameters important for the establishment of sperm production in adulthood.

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