HLA Class I-Restricted and Tumor-Specific Cytotoxic T Lymphocytes from Metastatic Lymph Nodes of Esophageal Cancers

Author： Toh U. Yamana H. Nakao M. Imai Y. Seki N. Takasu H. Kaneshige T. Fujita H. Shirouzu K. Itoh K.

ISSN： 0008-8749

Source： Cellular Immunology, Vol.177, Iss.2, 1997-05, pp. : 137-143

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Abstract

This paper investigates the presence of HLA class I-restricted and tumor-specific cytotoxic T lymphocytes (CTL) in tumor sites of esophageal cancers. Five CTL lines were established from the metastatic lymph nodes or pleural effusion by incubation with interleukin-2 of tumor-infiltrating lymphocytes: cases 1 and 5, HLA-A26- and HLA-A33-restricted and squamous cell carcinoma (SCC)-specific CTL; case 2, HLA-Cw0102restricted and esophageal SCC-specific CTL; case 3, HLA-A24- and HLA-A26-restricted CTL recognizing histologically different tumor cells; and case 4, HLA-A26-restricted and esophageal SCC-specific CTL. These results suggest the existence of HLA class I-restricted and tumor-specific CTL in metastatic esophageal SCC.