Author: Khandoudi N. Percevault-Albadine J. Bril A.
Publisher: Academic Press
ISSN: 0022-2828
Source: Journal of Molecular and Cellular Cardiology, Vol.30, Iss.10, 1998-10, pp. : 1967-1977
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Abstract
The effects of thapsigargin (Tg) and cyclopiazonic acid (CPA), two selective blockers of the sarcoplasmic reticulum Ca2+-ATPase were studied in rabbit isolated perfused hearts. Tg and CPA were infused into the hearts for 60 min followed by 60 min of wash-out. Left-ventricular developed pressure (LVDP), left-ventricular end diastolic pressure (LVEDP) and the relaxation time constant,
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