Author: Buschmann T. Minamoto T. Wagle N. Fuchs S.Y. Adler V. Mai M. Ronai Z.
Publisher: Academic Press
ISSN: 0022-2836
Source: Journal of Molecular Biology, Vol.295, Iss.4, 2000-01, pp. : 1009-1021
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Abstract
Identification of Mdm2 and JNK as proteins that target degradation of wt p53 prompted us to examine their effect on mutant p53, which exhibits a prolonged half-life. Of five mutant p53 forms studied for association with the targeting molecules, two no longer bound to Mdm2 and JNK. Three mutant forms, which exhibit high expression levels, showed lower affinity for association with Mdm2 and JNK in concordance with greater affinity to p14ARF, which is among the stabilizing p53 molecules. Monitoring mutant p53 stability
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