Multi-targeted Antifolates Aimed at Avoiding Drug Resistance Form Covalent Closed Inhibitory Complexes with Human and Escherichia coli Thymidylate Synthases

Author： Sayre P.H.   Finer-Moore J.S.   Fritz T.A.   Biermann D.   Gates S.B.   MacKellar W.C.   Patel V.F.   Stroud R.M.  

Publisher： Academic Press

ISSN： 0022-2836

Source： Journal of Molecular Biology, Vol.313, Iss.4, 2001-11, pp. : 813-829

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