Author： Sánchez L. Perondini A.L.P.
Publisher： Academic Press
ISSN： 0022-5193
Source： Journal of Theoretical Biology, Vol.197, Iss.2, 1999-03, pp. : 247-259
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Abstract
In sciarids, all zygotes start development with the 3X;2A chromosome constitution, two of the three X chromosomes being of paternal origin. The elimination of either one or two paternal X chromosomes produces the X:A signal which determines development along the female (2X;2A) or male (X0;2A) pathway, respectively. A model is proposed in which a chromosomal factor (CF) positively interacts with the X chromosome(s) causing its/their elimination. The number of X chromosomes to be eliminated is controlled by a maternal factor (MF) which regulates the amount of free CF factor interacting with the X chromosomes. Imprinting refers to the inability of maternal X chromosomes to bind CF factor.
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