Synthesis of a Biochemically Important Aldehyde, 3,4-Dihydroxyphenylacetaldehyde

Author: Li S.W.   Spaziano V.T.   Burke W.J.  

Publisher: Academic Press

ISSN: 0045-2068

Source: Bioorganic Chemistry, Vol.26, Iss.1, 1998-06, pp. : 45-50

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Abstract

3,4-Dihydroxyphenylacetaldehyde (DOPAL) is an important precursor of the major brain metabolites of dopamine, 3,4-dihydroxyphenylacetic acid and 4-hydroxy-3-methoxy-phenylacetic acid. A new method for the synthesis of DOPAL from piperonal is described. We report for the first time the physical and chemical characteristics of DOPAL. Its importance for research in Parkinson's disease and Alzheimer's disease is discussed.

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