Author： Osoegawa K. Susukida R. Okano S. Kudoh J. Minoshima S. Shimizu N. de Jong P.J. Groet J. Ives J. Lehrach H. Nizetic D. Soeda E.
Publisher： Academic Press
ISSN： 0888-7543
Source： Genomics, Vol.32, Iss.3, 1996-03, pp. : 375-387
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
The major phenotypic features of Down syndrome have been correlated with partial trisomies of chromosome 21, allowing us to define the candidate gene region to a 4-Mb segment on the 21q22.2 band. We present here a high-resolution physical map with megabase-sized cosmid/PAC contigs. This ordered clone library has provided unique material for the integration of a variety of mappable objects, including exons, cDNAs, restriction sites, etc. Furthermore, our results have exemplified a strategy for the completion of the chromosome 21 map to sequencing.
Related content
By Hubert R.S. Mitchell S. Chen X.N. Ekmekji K. Gadomski C. Sun Z. Noya D. Kim U.J. Chen C. Shizuya H. Simon M. de Jong P.J. Korenberg J.R.
Genomics, Vol. 41, Iss. 2, 1997-04 ,pp. :
Access to resources
Recommend
By Sparkes R.L. Summer C.G. Boycott K.M. Zahorchak R.J. Bech-Hansen N.T.
Genomics, Vol. 68, Iss. 1, 2000-08 ,pp. :
Transcriptional Map of the 2.5-Mb CBR-ERG Region of Chromosome 21 Involved in Down Syndrome
By Dahmane N. Ghezala G.A. Gosset P. Chamoun Z. Dufresne-Zacharia M.-C. Lopes C. Rabatel N. Gassanova-Maugenre S. Chettouh Z. Abramowski V. Fayet E. Yaspo M.-L. Korn B. Blouin J.-L. Lehrach H. Poutska A. Antonarakis S.E. Sinet P.-M. Creau N. Delabar J.-M.
Genomics, Vol. 48, Iss. 1, 1998-02 ,pp. :
A 1.5-Mb Cosmid Contig of the CMT1A Duplication/HNPP Deletion Critical Region in 17p11.2-p12
Genomics, Vol. 34, Iss. 1, 1996-05 ,pp. :