Author: Achiron A. Mor F. Margalit R. Cohen I.R. Lider O. Miron S.
Publisher: Academic Press
ISSN: 0896-8411
Source: Journal of Autoimmunity, Vol.15, Iss.3, 2000-11, pp. : 323-330
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Abstract
Experimental autoimmune encephalomyelitis (EAE) was induced in Lewis rats either by active immunization with myelin basic protein (MBP) or by adoptive transfer using anti-MBP specific CD4+T cells. Treatment with human polyclonal immunoglobulins (IgG) effectively suppressed active EAE. Time-dependent experiments demonstrated that the effect of IgG was manifested only when treatment was given immediately after immunization; administration from day 7 after disease induction did not suppress the disease. In the adoptive transfer model of EAE, IgG had no effect
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