Antibody to the Mr 65,000 Isoform of Glutamic Acid Decarboxylase are Detected in Non-Insulin-Dependent Diabetes in Japanese

Author： Kasuga A. Maruyama T. Ozawa Y. Takei I. Falorni A. Lernmark A. Saruta T.

Publisher： Academic Press

ISSN： 0896-8411

Source： Journal of Autoimmunity, Vol.9, Iss.1, 1996-01, pp. : 105-111

Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.

Previous Menu Next

Abstract

It was recently reported that antibodies against glutamic acid decarboxylase (GADAb) have a high positive predictive value for insulin-dependency in non-insulin-dependent diabetic (NIDDM) patients. We studied 289 patients classified at onset as having NIDDM. Patients positive for GAD65Ab had a disease onset at a younger age, lower body mass index (BMI) and lower serum C-peptide concentration, and were more often treated with insulin. Among 73 insulin-treated patients, patients with lower C-peptide level ( n =30, C-peptide<0.9 ng/ml) showed a higher frequency of GAD65Ab (46.7%) than patients with normal C-peptide ( n =53, C-peptide>0.9; 7.5%, P <0.0001). The 206 remaining non-insulin-treated patients were divided into 48 short-duration (less than 5 years from diagnosis) and 158 long-duration patients. Frequency of GAD65Ab in short-duration patients (10.4%) was significantly higher than that in long-duration patients (3.2%, P <0.05). Among short-duration patients, there was no significant difference in C-peptide levels between GAD65-positive and negative patients (2.175 and 2.226 ng/ml). In conclusion, GAD65Ab, a marker of insulin deficiency, may predict the development of insulin dependency in non-insulin-dependent Japanese diabetic patients before serum C-peptide concentration decreases.