

Author: Kortenbruck G. Berger E. Speckmann E. Musshoff U.
Publisher: Academic Press
ISSN: 0969-9961
Source: Neurobiology of Disease, Vol.8, Iss.3, 2001-06, pp. : 459-468
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Abstract
Posttranscriptional editing of mRNA is a phenomenon that generates molecular heterogeneity and functional variety. With the intention to test if RNA editing plays a role in pathological processes, which contribute to seizure maintenance, we examined the ratio of the unedited (Q) to edited (R) form of the AMPA receptor subunit GluR2 and kainate receptor subunits GluR5 and GluR6 in the hippocampus and temporal cerebral cortex, both excised from patients with pharmacoresistant temporal lobe epilepsies. We compared the data with samples from nonepileptic human control tissue (autopsy tissue). The ratio of
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