Author： Manzoni C. Mennini T.
Publisher： Academic Press
ISSN： 1043-6618
Source： Pharmacological Research, Vol.35, Iss.2, 1997-02, pp. : 149-151
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Abstract
High-affinity glutamate reuptake in neurons and glial cells, a mechanism involved in the maintenance of physiological excitatory amino acid neurotransmission, can be inhibited by arachidonic acid (AA). We studied the effect of different doses (from 10 to 500 gm M ) of AA on L -[ 3 H]glutamate uptake in synaptosomes from rat cortex, rat cerebellum and mouse spinal cord. We found that AA inhibition was dose-dependent, but the IC 50 in the cortex differed significantly from those in the cerebellum and spinal cord (170±7.9 gm M vs 42.5±5.4 gm M and 34.7±2.2 gm M respectively). We therefore suggest that arachidonic acid modulates uptake differently in relation to the regional expression of the glutamate transporter subtypes.
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