Author： Chiarugi V. Magnelli L. Cinelli M.
Publisher： Academic Press
ISSN： 1043-6618
Source： Pharmacological Research, Vol.35, Iss.4, 1997-04, pp. : 257-261
Disclaimer: Any content in publications that violate the sovereignty, the constitution or regulations of the PRC is not accepted or approved by CNPIEC.
Abstract
Apoptosis is a fundamental cell program as important as growth, differentiation and quiescence. It regulates tissue development, homeostasis and it is a basic defence against cancer.The cell can undertake multiple apoptotic pathways, where different elements are involved. In this report, we would like to stress particularly that the p53/RB pathway and its complex, interplay with the bcl2 gene family, where paramount elements of apoptosis regulation are operating. It is generally believed that bcl2 blocks apoptosis at the level of the activation of ICE-(Interleukin Converting Enzymes)-like proteases [1,2].The interconnection between apoptosis and cell cycle is very important and complex and we will start the story from this very up-to-date point of view.
Related content
Access to resources
Recommend
By Qin Weiwei Lu Yonggang Zhan Chengyan Shen Tao Dou Lin Man Yong Wang Shu Xiao Chuanshi Bian Yunfei Li Jian
Cardiovascular Drugs and Therapy, Vol. 26, Iss. 1, 2012-02 ,pp. :
Current Pharmaceutical Design, Vol. 18, Iss. 30, 2012-10 ,pp. :