Coordination of Fibroblast Growth Factor Receptor 1 (FGFR1) and Fibroblast Growth Factor-2 (FGF-2) Trafficking to Nuclei of Reactive Astrocytes around Cerebral Lesions in Adult Rats

Author: Clarke W.E.   Berry M.   Smith C.   Kent A.   Logan A.  

Publisher: Academic Press

ISSN: 1044-7431

Source: Molecular and Cellular Neuroscience, Vol.17, Iss.1, 2001-01, pp. : 17-30

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Abstract

Traumatic injury to the adult central nervous system initiates a cascade of cellular and trophic events, culminating in the formation of a reactive gliotic scar through which transected axons fail to regenerate. Levels of fibroblast growth factor-2 (FGF-2), a potent gliogenic and neurotrophic factor, together with its full-length receptor, FGF receptor 1 (FGFR1) are coordinately and significantly increased postinjury in both nuclear and cytoplasmic fractions of extracted cerebral cortex biopsies after a penetrant injury. FGFR1 is colocalized with FGF-2 in the nuclei of reactive astrocytes, and here FGF-2 is associated with nuclear euchromatin. This study unequivocally demonstrates coordinate up-regulation and trafficking of FGF-2 and full-length FGFR1 to the nucleus of reactive astrocytes in an in vivo model of brain injury, thereby implicating a role in nuclear activity for these molecules. However, the precise contribution of nuclear FGF-2/FGFR1 to the pathophysiological response of astrocytes after injury is undetermined.

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